РОЛЬ ИНФЕКЦИЙ В РАЗВИТИИ АРТРОГРИПОЗА (обзор литературы)

Аннотация

Артрогрипоз занимает одно из ведущих мест среди врождённых деформаций скелета. Описаны случаи связи заболевания с различными патогенами, включая ZIKV, Akabane virus и др. Показано влияние ВУИ на развитие артрогрипоза и приведены описания его молекулярных механизмов. Приведены результаты анализа литературы о связи инфекций с развитием артрогрипоза из баз данных PubMed и РИНЦ и поисковиков Google и Yandex. Рассмотрены этиологически значимые микроорганизмы, распространенность патологии с учетом данных сероконтроля популяций животных. Описаны клинические проявления, лабораторные признаки и прогностические факторы, описаны вирусы, провоцирующие артрогрипоз у животных. Показано широкое географическое распространение возбудителей, способных спровоцировать развитие артрогрипоза. Анализ литературы демонстрирует, что наряду с известными вирусами человека: краснухи, ZIKV следует принимать во внимание вирусы, патогенные для животных, поскольку они могут стать источником появления новых штаммов вируса, патогенных для человека. Представляет практический интерес дальнейшее детальное изучение этиологии и патогенеза заболевания с целью разработки методов клинической лабораторной диагностики, лечения и профилактики артрогрипоза.

Annotation

Arthrogryposis is one of the leading congenital skeletal deformities. Cases of the disease association with various microbial agents, including Zika virus, Akabane virus and others are described. The influence of intrauterine infection on the development of arthrogryposis is shown and descriptions of its molecular mechanisms are provided. The review presents the results of the literature analysis on the association of infections with the development of arthrogryposis from the PubMed and RINTS databases and the Google and Yandex search engines. Etiologically significant microorganisms, the prevalence of pathology taking into account the data of serocontrol of animal populations are considered. Clinical manifestations, laboratory signs and prognostic factors are described, viruses that provoke arthrogryposis in animals are described. A wide geographic distribution of pathogens that can provoke the development of arthrogryposis is shown. The literature analysis demonstrates that along with the known human viruses: rubella, Zika virus, it is necessary to take into account viruses pathogenic for animals, as they can become a source of new strains of the virus pathogenic for humans. Further detailed study of both the etiology and pathogenesis of the disease in order to establish possible methods of treatment and prevention of arthrogryposis is of practical interest
Key words: review; arthrogryposis; Zika virus; intrauterine infection

Об авторах

Список литературы

ЛИТЕРАТУРА (пп. 2-15, 17 – 18, 21 — 23, 25 — 62, 54 – 76 см. REFERENCES)

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