Аннотация
Цель исследования. Оценить распространенность клональных комплексов Streptococcus agalactiae среди беременных женщин, а также охарактеризовать профили устойчивости изолятов к противомикробным препаратам и спектр детерминирующих её генов.
Материалы и методы. Проведено исследование 55 клинических изолятов S. agalactiae из коллекции ФБУН МНИИЭМ им. Г.Н. Габричевского, выделенных в 2025 году в ходе планового обследования беременных женщин, вставших на учет в женских консультациях
г. Москвы.
Полученные результаты. Проведенное исследование выявило значительное генетическое разнообразие штаммов S. agalactiae и высокий уровень резистентности к макролидам и линкозамидам среди беременных женщин в Москве. Наряду с глобально распространенным комплексом СС19, доминирующую позицию занял клональный комплекс СС452, что указывает на особенности локальной эпидемиологии.
Заключение. Высокий уровень резистентности к макролидам/линкозамидам и доминирование клонального комплекса CC452 диктуют необходимость применения бензилпенициллина в качестве препарата выбора для антибиотикопрофилактики и подчеркивают важность непрерывного молекулярно-эпидемиологического мониторинга S. agalactiae в регионе.
Annotation
The aim of the study. To evaluate the prevalence of Streptococcus agalactiae clonal complexes among pregnant women, as well as to characterize the profiles of antimicrobial resistance of isolates and the spectrum of genes determining it.
Materials and methods. A study of 55 clinical isolates of S. agalactiae from the collection of the G. N. Gabrichevsky Research Institute for Epidemiology and Microbiology, isolated in 2025 during a planned examination of pregnant women enrolled in antenatal clinics in Moscow, was conducted.
The results obtained. The study revealed a significant genetic diversity of S. agalactiae strains and a high level of resistance to macrolides and lincosamides among pregnant women in Moscow. Along with the globally widespread CC19 complex, the clonal CC452 complex has taken the dominant position, which indicates the peculiarities of local epidemiology.
Conclusion. The high level of resistance to macrolides/lincosamides and the dominance of the CC452 clonal complex dictate the need to use benzylpenicillin as the drug of choice for antibiotic prophylaxis and emphasize the importance of continuous molecular and epidemiological monitoring of S. agalactiae in the region.
Key words: Streptococcus agalactiae; clonal complexes; antibiotic resistance; group B streptococcus; pregnant women; molecular epidemiology; CC452; macrolides; lincosamides; resistance genes
Список литературы
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