Резистентность стрептококков группы viridans при респираторных инфекциях

Аннотация

Условно-патогенные микроорганизмы продолжают оставаться основными возбудителями многих форм бактериальных инфекций. Эпидемиологические исследования свидетельствуют о возрастании числа случаев отсутствия этиологически значимых микроорганизмов при выраженной клинической картине респираторной инфекции. При данных обстоятельствах назначение эмпирической антибиотикотерапии может привести к распространению устойчивых к противомикробным препаратам штаммов и увеличению продолжительности лечения. Выходом из сложившейся ситуации  является изучение лекарственной чувствительности стрептококков группы viridans – комменсалов орофарингеальной микрофлоры. Изучение минимальной ингибирующей концентрации показало, что высокую активность в отношении Str. salivarius и  Str. anginosis проявляет меропенем и цефотаксим – к ним не было обнаружено ни одного резистентного штамма. Большинство штаммов Str. anginosis были резистентны к офлоксацину, азитромицину и левофлоксацину, в то время как изоляты Str. salivarius проявляли вариабельную чувствительность к этим препаратам. Информация о резистентности является теоретической основой знаний, определяющей выбор оптимальной антибиотикотерапии.

Annotation

Opportunistic microorganisms continue to be the main causative agents of many forms of bacterial infections. Epidemiological studies indicate an increase in the number of cases of the absence of etiologically significant microorganisms with a pronounced clinical picture of respiratory infection. Under these circumstances, prescribing empirical antibiotic therapy may lead to the spread of antimicrobial-resistant strains and an increase in the duration of treatment. The way out of this situation is to study the drug sensitivity of streptococci of the viridans group – commensals of the oropharyngeal microflora. The study of the minimum inhibitory concentration showed that meropenem and cefotaxime show high activity against Str. salivarius and Str. anginosis – no resistant strains were found to them. Most strains of Str. anginosis were resistant to ofloxacin, azithromycin and levofloxacin, while isolates of Str. salivarius showed variable sensitivity to these drugs. Information about resistance is the theoretical basis of knowledge that determines the choice of optimal antibiotic therapy.

Keywords: Str. salivarius, Str. anginosis, antibiotic resistance.

Об авторах

Список литературы

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