СКРИНИНГОВАЯ ДИАГНОСТИКА РАКА КИШЕЧНИКА ПО РЕЗУЛЬТАТАМ МЕТАЭКСПОСОМНОГО ИССЛЕДОВАНИЯ

Аннотация

Проведено газо-хроматографическое масс-спектрометрическое исследование крови 82 пациентов на содержание компонентов клеточной стенки микроорганизмов в крови. В основную группу были включены 43 пациента с диагнозом рак кишечника, 39 человек были отобраны в группу сравнения. Возраст пациентов в группах составил от 48 до 75 лет (средний возраст 62+10 лет). Статистически значимых отличий в исследуемых группах по возрасту не найдены. Гендерные различия не учитывались. Построены математические модели линейного дискриминантного анализа концентраций компонентов клеточной стенки в крови, позволяющие проводить предиктивную диагностику рака кишечника по диагностическим коэффициентам с точностью 100%. Построена дифференциальная модель линейного дискриминантного анализа, позволяющая диагностировать стадии рака кишечника с точностью 82,9%

Annotation

A gas chromatographic mass spectrometric study of the blood of 82 patients was carried out to determine the content of microorganism
cell wall components in the blood. 43 patients diagnosed with colon cancer were selected into the main group, and 39 people were
selected into the comparison group. The age of patients in the groups ranged from 48 to 75 years (average age 62+10 years). No
statistically significant differences were found in the study groups by age. Gender differences were not taken into account. Mathematical
models of linear discriminant analysis of the concentrations of cell wall components in the blood have been constructed, allowing for
predictive diagnosis of intestinal cancer using diagnostic coefficients with 100% accuracy. A differential linear discriminant analysis
model has been constructed that allows diagnosing the stages of colon cancer with an accuracy of 82.9%.
Key words: colon cancer; OMIK technologies; metaexposomics; small molecules of microbial origin; gas chromatography-mass
spectrometry; linear discriminant analysis

Об авторах

Список литературы

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